Chronic Lithium Treatment Inhibits Pilocarpine-Induced Mossy Fiber Sprouting in Rat Hippocampus
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چکیده
منابع مشابه
Lovastatin Modulates Glycogen Synthase Kinase-3β Pathway and Inhibits Mossy Fiber Sprouting after Pilocarpine-Induced Status Epilepticus
This study was undertaken to assay the effect of lovastatin on the glycogen synthase kinase-3 beta (GSK-3β) and collapsin responsive mediator protein-2 (CRMP-2) signaling pathway and mossy fiber sprouting (MFS) in epileptic rats. MFS in the dentate gyrus (DG) is an important feature of temporal lobe epilepsy (TLE) and is highly related to the severity and the frequency of spontaneous recurrent ...
متن کاملKindling & mossy fibre sprouting in the rat hippocampus following hot water induced hyperthermic seizures.
BACKGROUND & OBJECTIVES Hot water epilepsy (HWE) is well recognized reflex epilepsy with possible genetic susceptibility. Rat model and human experimentation had proven that HWE is a type of hyperthermic seizure with possible kindling on repeated stimulation in animals. The present study was undertaken to investigate kindling associated with hyperthermic seizures induced by repeated hot water s...
متن کاملGABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.
In the adult rat hippocampus, granule cell mossy fibers (MFs) form excitatory glutamatergic synapses with CA3 principal cells and local inhibitory interneurons. However, evidence has been provided that, in young animals and after seizures, the same fibers can release in addition to glutamate GABA. Here we show that, during the first postnatal week, stimulation of granule cells in the dentate gy...
متن کاملMossy fiber sprouting in rats hippocampus of subclinical seizures following hypoxic brain injury
1 Department of Neurology, Luzhou Medical College, Luzhou, 646000, China 2 Center for Nuclear Receptors and Cell Signaling, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA 3 Department of Neurology, The first affiliated hospital of Chongqing medical university, Chongqing, 40016, China 4 Department of otolaryngology, Guizhou Provincial People's Hospital, Guiyang, 550002, China 5 ...
متن کاملThe Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
OBJECTIVE Our primary objective is to verify whether 5-HTR6 is involved in the development of mossy fiber sprouting (MFS), and to determine how the progression of MFS is affected by 5-HTR6. METHODS A total of 90 male adult Sprague-Dawley rats were allocated into either the control group (n=36) or the epileptic group (n=54). Status epilepticus (SE) of rats was induced by the intraperitoneal (i...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2003
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300189